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Niuhuangjiedu Any Adverse Reactions Film

Niuhuangjiedu film by the bezoar, realgar, and more than 20 kinds of borneol Traditional Chinese medicine Composed of proprietary Chinese medicines, is commonly used in toxicity to clinical medicine, commonly used in sore throat, red eyes and swelling, constipation, red and yellow tongue, dizziness, wind, fire, toothache and other diseases. National Drug Classification provides Niuhuangjiedu film is non- Prescription drugs , People buy convenience, use a wide range.

Order to improve people's understanding of the drug, the authors collected from 1994 to 2007, domestic public offering of a variety of medical journals in the relevant literature on the adverse reactions reported Niuhuangjiedu films: 1994 to 2007 period, total reported bezoar 58 cases of adverse reactions detoxification chip. 33 patients were male, with a proportion of 56.9%, female 25 cases, 43.1% of the total number of patients aged from 3 months to 64 years, mean age 29 years, 32 cases of abnormal amount of medication, with a proportion of 55.2%.

Toxic reactions in 5 cases, clinical manifestations were oral cavity, esophagus, stomach erosion, mucosal swelling and bleeding, liver atrophy, oliguria of renal injury, proteinuria, hematuria, eyelid edema, skin flushing, abdominal pain, bowel bleeding, cyanosis, limbs cold, exhaustion, etc..

Allergic reactions in 22 cases, clinical manifestations of skin papules and plaques for the body, itching, facial, trunk heavier. 10 cases of drug eruption, fixed spotted in 5 cases, distributed in the face, trunk, such as beans Great Red Spot, clear boundary with itching; allergic-like herpes alone in 1 case, exfoliative dermatitis in 1 case, 1 case of black disease, heavy Polymorphic exudative erythema in 4 cases.

8 cases of anaphylactic shock, clinical manifestations were as shortness of breath, chest tightness, difficulty breathing, lips purple, pale skin and mucous membrane cyanosis body, limbs Jueleng, sweating, irritability, confusion, urine incontinence, tendon reflexes, and apnea.

Digestive system adverse events in 8 cases, main clinical manifestations of upper gastrointestinal mucosal injury, discomfort, pain, nausea, vomiting, vomit thing was brown, and then blood in the stool. Endoscopy, microscopy gastric hyperemia, edema, erosion and bleeding face. Part of the case is elevated aminotransferases, Hepatic veno-occlusive disease, drug-induced liver disease.

4 cases of urinary tract adverse events, clinical manifestations were lumbar pain, urinary frequency, urgency, hematuria, urine occult blood examination, in some cases accompanied by epistaxis, severe cases can cause renal organ damage.

Nervous system response in 7 cases, clinical manifestations were as lethargy, vomiting, pale gray, shortness of breath, skin elasticity is poor, extremities cold, or breathing difficulties, confusion, limbs twitch, consciousness disorders, sometimes sit-mouthed sometimes incoherent, irrelevant answers. Another response in the blood system

1 case, showing thrombocytopenia and pure red cell aplasia anemia. Respiratory Reaction in 2 cases, main clinical manifestations of bronchial asthma-like symptoms: shortness of breath, difficulty breathing, chest tightness, cough, slightly liquid foam material is white, pale, lips cyanosis, palpitations, can not be supine. 1 case of addiction, severe withdrawal symptoms after stopping again quickly relieve the symptoms after medication.

Taste Niuhuangjiedu film 8 Traditional Chinese medicine In realgar Department of arsenic compounds, toxic. Easy and tissues of arsenic trioxide in the sulfhydryl enzyme combination, inhibit the enzyme activity, causing cell metabolism disorder, leading to the central nervous, cardiovascular, gastrointestinal, liver and kidney toxicity and other organizations.

Arsenic accumulation in the body has a strong role, such as long-term or large doses, which produce intoxication. The adverse reactions in 55.2% of the cases were caused by overdose, it must not be excessive in taking medication even when not Jiufu or abuse, to ensure drug safety.

Niuhuangjiedu tablets in preparation and storage, the measures could lead to improper AsS realgar oxidation of As2O3, and As2O3 namely arsenic, a poison, its toxic effects can affect the nervous system, digestive system, blood system and urinary system and so on. Therefore, enterprises should be carried out strictly in accordance with the production process of production, circulation should be required in all store. On the young and old and women or frail patients should reduce the dosage of medication to reduce the number. Asked in detail about his former drug allergies, patients should be reminded of high sensitivity in patients with body mass to stop taking these medicines.

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